Mammalian Zinc Transporters

Structural Overview Of Mammalian Zinc Metalloproteinases

Matrix metalloproteinases (MMP) are crucial for homeostasis (tissue remodelling and repair, bone growth, wound healing, etc.) and pathology (metastasis, angiogenesis, aneurysm rupture, etc.). Upregulated MMPs from macrophages are thus a two-edged sword, playing both defensive and aggressive roles. The related family of ADAMs (a disintegrin and a metalloproteinase) is sometimes overlooked becaus...

Mammalian Sugar Transporters

Glucose represents the major energy source of mammalian cells. Due to its hydrophilic nature, glucose requires specific transporters in order to cross cellular membranes. Such transport is, in the case of glucose and also other monosaccharides, mediated by energy-coupled as well as facilitative mechanisms represented by protein families of sodium-driven sugar cotransporters (SGLTs) and glucose ...

[Overview of and update on the physiological functions of mammalian zinc transporters].

In recent years, a number of mammalian zinc transporters have been molecularly characterized. This has brought about major advances in our understanding of the tight regulation of cellular zinc homeostasis and the pivotal roles zinc transporters play in a variety of biological events. Mammalian zinc transporters are classified into two families: the ZRT, IRT-like protein (ZIP) family and the Zn...

Targeting of mammalian glucose transporters.

Glucose transporters in mammalian brain.

(;lucose is the primary energy source for mammalian brain and a continuous supply is vital for normal cerebral function. At rest, the brain is responsible for metabolizing up to 60% of the available circulating glucose, and the efficient transport of glucose across the blood-brain barrier (BRH) and into the various cells that make up the brain is essential. Of the six facilitative glucose trans...